Neurodegenerative genetic disorder

January 4th, 2012 by lu | Posted in General |

Diseases in the article Trinucleotide repeat disorder. While polyglutamine-repeat diseases encompass many different neurodegenerative genetic disorder, there are many more it does not apply to. The genetics behind each disease are different and often unknown.
Current research, often in transgenic animal models, implicates both apoptotic and non-apoptotic pathways in neurodegeneration. Different diseases may enter these pathways at different points, but once triggered can lead to interdependent pathways of cell death.
Transgenic mice that express disease-causing genes recapitulate many features of these diseases. This review provides an overview of transgenic mouse models of familial amyotrophic lateral sclerosis, familial Alzheimer’s disease, and Huntington’s disease and the emerging insights relevant to the underlying molecular mechanisms of these diseases.